As a well-known herbal supplement, bezoar has always been revered in traditional Chinese medicine. It is said that its healing property was unintentionally discovered by Bian Que, a highly-skilled doctor in ancient China. Since then it has been used medicinally for more than 2000 years. Today it still works like a charm in the treatment of various diseases like encephalitis and hemorrhagic fever. When it comes to emergency treatments, Chinese medicine is probably the last one to be thought of. In fact, TCM has 3 first-aid secret weapons – An Gong Niu Huang Wan (AGNH), Zi Xue Dan, and Zhi Bao Dan. And statistically there are more than 200 kinds of bezoar-based Chinese patent drugs currently, such as Niu Huang Shang Qing Wan, Niu Huang Qing Xin Wan, Qian Jin San, Liu Shen Wan, and so on.
Modern pharmacological actions of cow gallstone
1. It has sedative, anticonvulsant and antipyretic effects;
2. It can enhance the myocardial contractility of isolated frog heart;
3. Its main component of bilirubin has antihypertensive and heartbeat-inhibiting effects;
4. Its water soluble portion of SMC has gallbladder contractile function;
5. Its cholic acid, in particular deoxycholate, can slack the sphincter of Oddi and then promote bile secretion;
6. Taurine has a significant protective effect on acute and chronic liver damage induced by carbon tetrachloride in rats;
7. Intravenously it can significantly increase red blood cells count in rabbits;
8. It has inflammatory, hemostatic, and lipid-lowering effects.
Sample calculus bovis herbal remedies
The Chinese Pharmacopoeia believes that bezoar is sweet in flavor and cool in nature and it covers meridians of heart and liver. Basic functions are clearing away the heart-fire, eliminating phlegm, inducing resuscitation, cool the liver, dispelling wind, and relieve internal heat or fever. Main bezoar uses and indications include fever-induced coma, stroke, epilepsy seizures, cramp, mania, sore throat, mouth sores, and boils. Recommended dosage is from 0.15 to 0.35g in pills or powder.
1. An Gong Niu Huang Wan from Wen Bing Tiao Bian (Detailed Analysis of Warm Diseases). It is combined with She Xiang (musk), Bing Pian (borneol), Zhu Sha (cinnabar), Huang Lian (Coptis Root), Zhi Zi (Gardenia), etc. to treat the invasion of pericardium by heat, stroke, convulsions, and epilepsy, in which the blocked heart orifice induces coma, delirium, fever, irritability, trismus, difficulty moving tongue, choking because of phlegm in throat, etc.
2. Niu Huang San from Zheng Zhi Zhun Sheng (The Level-line of Patterns & Treatment). It is formulated with cinnabar, Quan Xie (Scorpion), Gou Teng (Cat’s Claw), etc. to cure acute infantile convulsions, in which main symptoms include high fever, coma, convulsions, and so on.
3. Niu Huang Jie Du Pian or Wan from Quan Guo Zhong Cheng Yao Chu Fang Ji (National Collection of Chinese Herbal Prepared Medicines). It is matched with Huang Qin (Scutellaria Baicalensis), Xiong Huang (realgar), Da Huang (Rheum Palmatum), etc. to heal stagnated fire toxin induced mouth and tongue sore, sore throat, and toothache.
4. Zhu Huang San from Jiang Nang Cuo Yao (Brimson Bag Brief Points). It is used along with pearl to cure sore throat and ulcers.
5. Xi Huang Wan from Wai Ke Zheng Zhi Quan Sheng Ji (Compendium of Syndrome Identification and Treatment of External Medicine). It is put together with musk, Ru Xiang (Frankincense), and Mo Yao (Myrrh) to treat breast cancer, buboes, subcutaneous nodule, deep multiple abscess, scrofula, malignant sore, etc.
Bezoar side effects and contraindications
An overdose of bezoar can cause poisoning, manifested as cramps, increased gastrointestinal motility, convulsions, diarrhea, and increased skeletal muscle activity. In severe cases, it has inhibitory effect instead, such as fall of blood pressure, decrease of red blood cells and hemoglobin count, cardiac arrhythmia, semicoma or coma, and finally death due to the result of respiratory and circulatory failure. TCM wise, use cow bezoar with caution during pregnancy and in the case of loose stool due to spleen deficiency. Besides, it shouldn’t be used in non-excess heat syndrome.