Dosing & Uses of zolpidem(Ambien)

Dosage Forms & Strengths

tablet, immediate-release: Schedule IV

  • 5mg (Ambien)
  • 10mg (Ambien)

tablet, extended-release: Schedule IV

  • 6.25mg (Ambien CR)
  • 12.5mg (Ambien CR)

tablet, sublingual: Schedule IV

  • 1.75mg (Intermezzo)
  • 3.5mg (Intermezzo)
  • 5mg (Edluar)
  • 10mg (Edluar)

oral spray: Schedule IV

  • 5mg/spray (Zolpimist)
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Sleep initiation

Immediate-release tablet, sublingual tablet, and oral spray

  • Dosing for PO (Ambien), SL (Edluar), and oral spray (Zolpimist)
  • Women: 5 mg PO/SL/oral spray qHS
  • Men: Consider 5 mg PO/SL/oral spray qHS; may use 10 mg PO/SL/oral spray qHS if needed

Extended-release (Ambien CR)

  • Women: 6.25 mg PO qHS
  • Men: Consider 6.25 mg PO qHS; may use 12.5 mg PO qHS; not to exceed 12.5 mg/day

Dosing considerations (Ambien, Ambien CR)

  • Use lowest effective dose; take only once per night immediately before bedtime with at least 7-8 hr remaining before the planned time of awakening
  • In some patients, higher morning blood levels following use of 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness
  • Total dose should not exceed 10 mg once daily immediately before bedtime; should be taken as single dose and should not be readministered during same night

Insomnia (Intermezzo)

Insomnia when a middle of the night awakening is followed by difficulty returning to sleep

Women: 1.75 mg SL PRN; not to exceed 1 dose/night

Men: 3.5 mg SL PRN; not to exceed 1 dose/night

Dosing considerations (Intermezzo)

  • Use only when ≥4 hr of bedtime remain before awakening
  • Do not take if alcohol has been consumed or with any other sleep aid
  • Concomitant with CNS depressants: 1.75 mg SL PRN; not to exceed 1 dose/night
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Dosing Modifications

Renal impairment

  • Dose adjustment may not be necessary; monitor

Hepatic impairment

  • Immediate-release: 5 mg immediately before bedtime
  • Extended-release: 6.25 mg immediately before bedtime
  • Sublingual (Edluar): 5 mg immediately before bedtime
  • Sublingual (Intermezzo): 1.75 mg once at night if ≥4 hr remain before awakening

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